TryptageniX develops fermentation routes for natural-product classes where access is limited by scarce, variable, or difficult source material.
Voacanga africana and Catharanthus roseus run the same pathway. Trace yields, slow harvests, and structural complexity sit between every botanical source and a usable supply.
Run the pathway in yeast: secologanin to strictosidine, into stemmadenine acetate, then the tabersonine and catharanthine fork.
Mitragyna speciosa leaf chemistry is dominated by a few abundant alkaloids. Minor members are interesting and hard to access at scale.
Route corynanthe-type chemistry through fermentation instead of leaf extraction.
Ergot fungi run a slow, specialized program. Access to the ergoline scaffold has stayed narrow for a century.
Develop fermentation routes into agroclavine and the ergoline building blocks that feed future clinical NCEs.
Salvia divinorum chemistry is sparse in nature and structurally unusual. Wild leaf supply is limited.
Open repeatable access to salvinorin-family chemistry through engineered yeast.Rare natural products can reveal important biology long before they are practical to access. Better routes turn scarce chemistry into material that can be compared, characterized, and expanded.
Consistent access makes it easier to compare rare natural products across studies and time.
Fermentation routes reduce dependence on slow, variable, or sensitive source chains.
Better access makes neighboring natural-product and NCE space easier to evaluate.
